Keeping astronauts safe merits significant expenditure. But how much? There is a potentially unlimited set of testing procedures, precursor missions, technological improvements, and other protective measures that could be implemented before allowing human beings to once again try flying to other worlds. Were we to adopt all of them, we would wind up with a human spaceflight program of infinite cost and zero accomplishment. In recent years, the trend has moved in precisely that direction, with NASA’s manned spaceflight effort spending more and more to accomplish less and less. If we are to achieve anything going forward, we have to find some way to strike a balance between human life and mission accomplishment.